Publications


2023

Gasdermins gone wild: new roles for GSDMs in regulating cellular homeostasis

Weindel et al. Trends in Cell Biology


2022

SRSF6 balances mitochondrial-driven innate immune outcomes through alternative splicing of Bax

Wagner et al., Elife

Mitochondrial ROS promotes susceptibility to infection via gasdermin D-mediated necroptosis

Weindel et al., Cell


2021

Galectin-8 senses phagosomal damage and recruits selective autophagy adapter Tax1BP1 to control Mycobacterium tuberculosis infection in macrophages

Bell et al., mBio

Mitochondria: Powering the Innate Immune Response to Mycobacterium tuberculosis infection

Patrick and Watson, Infection and Immunity

Global transcriptomics uncovers distinct contributions from splicing regulatory proteins to the macrophage innate immune response

Wagner, Scott, West et al., Frontiers in Immunology

The opportunistic intracellular bacterial pathogen Rhodococcus equi elicits type I interferons by engaging cytosolic DNA sensing in macrophages

Vail et al., PLOS Pathogens


2020

TRIM14 is a Key Regulator of the Type I IFN response during Mycobacterium tuberculosis infection

Hoffpauir et al., Journal of Immunology

LRRK2 maintains mitochondrial homeostasis and regulates innate immune responses to Mycobacterium tuberculosis

Weindel, Bell et al., Elife


2019

The splicing factor hnRNP M is a critical regulator of innate immune gene expression in macrophages

West et al., Cell Reports

Exploring the “multiple-hit hypothesis” of neurodegenerative disease: bacterial infection comes up to bat

Patrick et al., Frontiers in Cellular and Infection Microbiology


2018

Quantitative yeast genetic interaction profiling of bacterial effector proteins uncovers a role for the human retromer in Salmonella infection

Patrick et al., Cell Systems


2016

For better or worse: cytosolic DNA sensing during intracellular bacterial infection induces potent innate immune responses

Patrick, Bell et al., Journal of Molecular Biology


Earlier worK from kristin and robbie (2017-2001)

The histone variant H2A.Z promotes splicing of weak introns (Patrick)

The cytosolic sensor cGAS detects Mycobacterium tuberculosis DNA to induce type I interferons and activate autophagy (Watson)

Genetic interaction mapping reveals a role for the SWI / SNF nucleosome remodeler in spliceosome activation in fission yeast (Patrick)

The ubiquitin ligase parkin mediates resistance to intracellular pathogens (Watson)

Extracellular M. tuberculosis DNA targets bacteria for autophagy by activating the host DNA-sensing pathway (Watson)

Hierarchal modularity and the evolution of genetic interactomes across species (Patrick)

Distinct and overlapping roles for two Dicer-like proteins in RNA interference pathways of the ancient eukaryote Trypanosoma brucei (Patrick)

Interaction of Campylobacter jejuni with host cells. (Watson)

Campylobacter jejuni survives within epithelial cells by avoiding delivery to lysososomes (Watson)

Genomic rearrangements and transcriptional analysis of spliced leader associated retrotransposon in RNA interference-deficient Trypanosoma brucei (Patrick)

A MyD88-deficient mouse model reveals a role for Nramp1 in Campylobacter jejuni infection (Watson)

Unique features of a highly pathogenic Campylobacter jejuni strain (Watson)

Sexual dimorphism in campylobacteriosis (Watson)

Signal transduction in Campylobacter jejuni-induced cytokine production (Watson)

Rgg influences expression of multiple regulatory loci to co-regulate virulence factor expression in streptococcus pyogenes (Watson)

Role of tyrosine kinases and the tyrosine phosphatase SptP in the interaction of Salmonella with host cells (Watson)

Identification of Rgg-regulated exoproteins of Streptococcus pyogenes (Watson)